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Newcastle Mitochondrial Quality of Life Measure (NMQ)
Availability
Please visit this website for more information about the instrument: Newcastle Mitochondrial Quality of Life Measure
Classification
Supplemental - Highly Recommended: Mitochondrial Disease (Mito)
Recommendations for use: Indicated for studies requiring a mitochondrial disease-specific health-related quality of life measure.
Short Description of Instrument
Mitochondrial disease-specific health-related quality of life self-report measure consisting of 63 items within 16 unidimensional domains.
Scoring and Psychometric Properties
Scoring: Completion of NMQ is simple and quick (on average 3-5 min) and scoring of the questionnaire is similar to that of the SF-36. Each domain is transformed into a 0-100 scale on the assumption that each question carries equal weight, thus the higher the percentage NMQ domain score the greater the perceived quality of life and health status.
 
Psychometric Properties: The psychometric evaluation of NMQ provides good evidence of both reliability and validity. Internal consistency of each of the domains exceeded the 0.7 threshold and item-total correlations exceeded 0.2 for all items. Each domain demonstrates good internal reliability (Cronbach's alpha >= 0.83) and construct validity.
Rationale/Justification
Strengths: Focuses on symptoms-specific features of mitochondrial disease, completed in 5 minutes.
 
Weaknesses: NMQ domains of activities of daily living, energy, communication, pain, migraine and stigma show poor correlation with their comparative SF-36 health concepts.
References
Key Reference:
Elson JL, Cadogan M, Apabhai S, Whittaker RG, Phillips A, Trennell MI, Horvath R, Taylor RW, McFarland R, McColl E, Turnbull DM, Gorman GS. Initial development and validation of a mitochondrial disease quality of life scale. Neuromuscul Disord. 2013 Apr;23(4):324-9.
 
Document last updated March 2024